Several victims were trapped and had to be extracted by firefighters and EMS crews, responding to the intersection of Route 1 and Randolph Avenue, around 12:10 p.m., reports say.
At least one crash victim was airlifted by Northstar medevac helicopter to Robert Wood Johnson University Medical Center in New Brunswick, reports said.
Eastbound lanes of Route remained closed about 3 p.m. as police tried to determine the cause of the crash.
Investigators from the Middlesex County Prosecutor's Office also were called to the crash scene.
A total of 11 crash victims were taken to area hospitals, some of them with non-life-threatening injuries, according to an unconfirmed count.
This is a developing news story.
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